
Tablet Defects Detectable
- Cracks: Small or large fractures on the tablet surface that can compromise structural integrity or dosage accuracy.
- Chipping: Breakage or loss of small pieces, typically along the edges, which may affect appearance and dosage.
- Capping: Separation of the top or bottom portion of the tablet from the main body, often due to compression issues.
- Lamination: Splitting of the tablet into layers, indicating poor bonding of the tablet material.
- Sticking: Residue or material adhering to the tablet surface, often from the punch or die during compression.
- Picking: Small areas of the tablet surface missing or damaged, typically where material sticks to the punch face.
- Mottling: Uneven color distribution or spotting on the tablet surface, which can indicate inconsistent mixing or dye issues.
- Discoloration: Abnormal or unintended color changes that may suggest degradation, contamination, or formulation errors.
- Foreign Particles: Presence of contaminants or extraneous matter embedded in or on the tablet.
- Size/Shape Variations: Deviations from the intended dimensions or geometry (e.g., oval, round), affecting uniformity.
- Surface Imperfections: Pits, dents, or roughness that deviate from the expected smooth or coated finish.
- Double Impressions: Multiple or overlapping imprints caused by machine errors during compression.
- Broken Tablets: Tablets that are fully fractured or fragmented, rendering them unusable.
- Coating Defects: Issues with coated tablets, such as uneven coating, peeling, or blistering.
- Imprint Issues: Missing, incomplete, or illegible markings (e.g., logos, numbers) used for identification.
- Weight Variation: Visual signs of inconsistency in tablet thickness or size that may correlate with weight discrepancies.
Liquid Solution Defects Detectable
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Container Integrity Defects
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Cracks or Chips: Breaks in vials, ampoules, or syringes that could compromise sterility or lead to leakage.
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Seal Imperfections: Poorly fitted stoppers, crimps, or closures that might allow contamination or loss of product.
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Cosmetic Defects
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Scratches or Scuffs: Surface imperfections on containers that may not affect functionality but could impact perceived quality.
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Discoloration: Unexpected changes in the container or drug solution color, indicating potential degradation or contamination.
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Fill Level Issues
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Overfilling or underfilling of containers, which could affect dosing accuracy or suggest manufacturing inconsistencies.
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Foreign Matter in Solution
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Undissolved material, precipitates, or cloudiness in the drug solution, which could indicate formulation instability or contamination.
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Cake Appearance (Lyophilized Products)
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For freeze-dried drugs, inspection includes checking for irregularities like collapse, melt-back, or uneven cake structure, which could affect reconstitution or potency.
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Air Bubbles
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Excessive or unexpected air bubbles in liquid formulations, which might indicate improper filling or sealing processes.
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Labeling and Packaging Issues
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Misaligned, damaged, or missing labels that could lead to identification errors, though this is often a secondary focus in visual inspection.
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