Tablet Defects Detectable

 

  • Cracks: Small or large fractures on the tablet surface that can compromise structural integrity or dosage accuracy.
  • Chipping: Breakage or loss of small pieces, typically along the edges, which may affect appearance and dosage.
  • Capping: Separation of the top or bottom portion of the tablet from the main body, often due to compression issues.
  • Lamination: Splitting of the tablet into layers, indicating poor bonding of the tablet material.
  • Sticking: Residue or material adhering to the tablet surface, often from the punch or die during compression.
  • Picking: Small areas of the tablet surface missing or damaged, typically where material sticks to the punch face.
  • Mottling: Uneven color distribution or spotting on the tablet surface, which can indicate inconsistent mixing or dye issues.
  • Discoloration: Abnormal or unintended color changes that may suggest degradation, contamination, or formulation errors.
  • Foreign Particles: Presence of contaminants or extraneous matter embedded in or on the tablet.
  • Size/Shape Variations: Deviations from the intended dimensions or geometry (e.g., oval, round), affecting uniformity.
  • Surface Imperfections: Pits, dents, or roughness that deviate from the expected smooth or coated finish.
  • Double Impressions: Multiple or overlapping imprints caused by machine errors during compression.
  • Broken Tablets: Tablets that are fully fractured or fragmented, rendering them unusable.
  • Coating Defects: Issues with coated tablets, such as uneven coating, peeling, or blistering.
  • Imprint Issues: Missing, incomplete, or illegible markings (e.g., logos, numbers) used for identification.
  • Weight Variation: Visual signs of inconsistency in tablet thickness or size that may correlate with weight discrepancies.

Liquid Solution Defects Detectable


  • Container Integrity Defects
    • Cracks or Chips: Breaks in vials, ampoules, or syringes that could compromise sterility or lead to leakage.
    • Seal Imperfections: Poorly fitted stoppers, crimps, or closures that might allow contamination or loss of product.
  • Cosmetic Defects
    • Scratches or Scuffs: Surface imperfections on containers that may not affect functionality but could impact perceived quality.
    • Discoloration: Unexpected changes in the container or drug solution color, indicating potential degradation or contamination.
  • Fill Level Issues
    • Overfilling or underfilling of containers, which could affect dosing accuracy or suggest manufacturing inconsistencies.
  • Foreign Matter in Solution
    • Undissolved material, precipitates, or cloudiness in the drug solution, which could indicate formulation instability or contamination.
  • Cake Appearance (Lyophilized Products)
    • For freeze-dried drugs, inspection includes checking for irregularities like collapse, melt-back, or uneven cake structure, which could affect reconstitution or potency.
  • Air Bubbles
    • Excessive or unexpected air bubbles in liquid formulations, which might indicate improper filling or sealing processes.
  • Labeling and Packaging Issues
    • Misaligned, damaged, or missing labels that could lead to identification errors, though this is often a secondary focus in visual inspection.